Research use only. Not for use in humans or animals. All products and information on this site are provided strictly for in-vitro laboratory research purposes. They are not for use in humans or animals, and are not drugs, foods, cosmetics, or medical devices.
What Is TB-500? A Research Peptide Overview
TB-500 is a synthetic peptide related to thymosin β4 (Tβ4), a naturally occurring protein central to actin regulation inside cells. TB-500 corresponds to the active actin-binding region of thymosin β4 and is studied in laboratory models of cell migration and tissue repair. This overview covers what TB-500 is, how it relates to thymosin β4 and BPC-157, and how to source research-grade material.
TB-500 at a glance
| Property | Value |
|---|---|
| Name | TB-500 (thymosin β4 fragment / analog) |
| Related protein | Thymosin β4 (Tβ4), a 43-amino-acid actin-sequestering protein |
| Key motif | The actin-binding domain of Tβ4 |
| Appearance | White lyophilized powder |
TB-500 vs thymosin β4
This is the most common point of confusion. Thymosin β4 is the full 43-amino-acid protein. TB-500 refers to a synthetic peptide built around the actin-binding fragment of that protein — the part responsible for its actin-sequestering activity. In research literature the names are sometimes used interchangeably, but strictly, TB-500 is the shorter synthetic construct.
What TB-500 is studied for
In laboratory research (in-vitro and animal models), TB-500 is studied for its role in:
- Actin regulation — sequestering G-actin and influencing cytoskeletal dynamics.
- Cell migration — models of how cells move during tissue-repair processes.
- Angiogenesis — endothelial-cell behavior in vascular-model systems.
TB-500 offered here is a research chemical for laboratory use only. Not for use in humans or animals.
TB-500 vs BPC-157
TB-500 and BPC-157 are frequently studied together in tissue-repair research because they act through different proposed mechanisms: TB-500 through actin regulation and cell migration, BPC-157 through angiogenesis and nitric-oxide signaling. They are sometimes studied as a blend. For a full comparison, see BPC-157 vs TB-500 →.
TB-500 ships as a lyophilized (freeze-dried) powder. Researchers refer to the lot-specific COA and validated laboratory protocols for any handling observations.
How research-grade material is verified
Every batch from a credible US supplier should arrive with a third-party Certificate of Analysis (COA) for that exact lot. Peptide Technologies publishes a COA on every batch and ties it to a QR code on the vial. A complete COA reports:
- Identity — mass spectrometry (ESI-MS) confirming the observed mass matches the theoretical mass of the target sequence.
- Purity — reverse-phase HPLC, reported as percent peak area at a fixed wavelength (typically 220 nm). Research-grade material is ≥99% by area.
- Net content — gravimetric confirmation the vial holds the stated mass within tolerance.
- Endotoxin — LAL assay below research-grade thresholds.
If a vendor cannot show a lot-specific COA, you cannot verify what is in the vial. Browse the full COA library →
How to source research-grade material
For laboratory research, sourcing quality comes down to a few checks:
- Lot-specific COA from an accredited, independent laboratory — not a generic marketing PDF.
- HPLC purity ≥99% by peak area, with the chromatogram shown.
- US synthesis and finishing, so the chain of custody is documented end to end.
- Cold-chain shipping for lyophilized material, so the product arrives stable.
Peptide Technologies meets each of these and publishes a third-party COA for every lot. Browse the public COA library →
FAQ
What is TB-500?
TB-500 is a synthetic peptide related to thymosin β4, built around its actin-binding fragment. It is studied in laboratory models of cell migration and tissue repair.
Is TB-500 the same as thymosin β4?
Not exactly. Thymosin β4 is the full 43-amino-acid protein; TB-500 is a synthetic peptide based on its active actin-binding region. The names are sometimes used interchangeably in research.
What is the difference between TB-500 and BPC-157?
Both are studied in tissue-repair research but through different mechanisms: TB-500 in actin regulation and cell migration, BPC-157 in angiogenesis and nitric-oxide signaling.
How is TB-500 verified?
Research-grade TB-500 is verified by HPLC for purity, mass spectrometry for identity, and an LAL endotoxin assay, reported on a lot-specific third-party COA.
Is TB-500 a research chemical?
Yes. TB-500 supplied by Peptide Technologies is a research chemical for laboratory use only. Not for use in humans or animals.