Research use only. Not for use in humans or animals. All products and information on this site are provided strictly for in-vitro laboratory research purposes. They are not for use in humans or animals, and are not drugs, foods, cosmetics, or medical devices.
What Is CJC-1295? A Research Peptide Overview
CJC-1295 is a synthetic analog of growth-hormone-releasing hormone (GHRH), engineered for an extended half-life in laboratory systems. It is one of the most-discussed GH-secretagogue research peptides, largely because of two things researchers ask about constantly: the difference between its DAC and no-DAC forms, and its frequent pairing with ipamorelin. This overview covers both.
CJC-1295 at a glance
| Property | Value |
|---|---|
| Name | CJC-1295 (GHRH analog) |
| Class | Modified GHRH(1–29) analog |
| Forms | With DAC (drug-affinity complex) and without DAC ("no-DAC," also called mod-GRF 1-29) |
| Appearance | White lyophilized powder |
Research background
CJC-1295 is built on the GHRH(1–29) fragment (the same active region studied as sermorelin) with amino-acid substitutions that resist enzymatic breakdown. That substitution alone produces the no-DAC form. Adding a drug-affinity complex (DAC) — a chemical group that binds circulating albumin — further extends the half-life in laboratory systems, producing the with-DAC form.
CJC-1295 DAC vs no-DAC
| No-DAC (mod-GRF 1-29) | With DAC | |
|---|---|---|
| Half-life (lab systems) | Short (minutes) | Extended (days) |
| Studied alongside | Often paired with ipamorelin | Studied as a standalone long-acting analog |
| Research focus | Pulsatile GHRH-receptor signaling | Sustained receptor engagement |
The choice between forms in a study depends on whether the research question calls for short, pulse-like receptor activation or sustained engagement.
The CJC-1295 / ipamorelin pairing
CJC-1295 (no-DAC) is frequently studied together with ipamorelin, a growth-hormone secretagogue that acts on a different receptor (the ghrelin/GHS receptor). Because the two act through complementary pathways — GHRH-receptor and GHS-receptor — they are a common research pairing. See what is ipamorelin → for the companion overview.
What CJC-1295 is studied for
In laboratory and preclinical research, CJC-1295 is studied for:
- GHRH-receptor signaling and comparative half-life characterization.
- Somatotroph response in endocrine-model systems.
- Complementary secretagogue research when paired with a GHS-receptor agonist.
CJC-1295 offered here is a research chemical for laboratory use only. Not for use in humans or animals.
CJC-1295 ships as a lyophilized (freeze-dried) powder. Researchers refer to the lot-specific COA and validated laboratory protocols for any handling observations.
How research-grade material is verified
Every batch from a credible US supplier should arrive with a third-party Certificate of Analysis (COA) for that exact lot. Peptide Technologies publishes a COA on every batch and ties it to a QR code on the vial. A complete COA reports:
- Identity — mass spectrometry (ESI-MS) confirming the observed mass matches the theoretical mass of the target sequence.
- Purity — reverse-phase HPLC, reported as percent peak area at a fixed wavelength (typically 220 nm). Research-grade material is ≥99% by area.
- Net content — gravimetric confirmation the vial holds the stated mass within tolerance.
- Endotoxin — LAL assay below research-grade thresholds.
If a vendor cannot show a lot-specific COA, you cannot verify what is in the vial. Browse the full COA library →
How to source research-grade material
For laboratory research, sourcing quality comes down to a few checks:
- Lot-specific COA from an accredited, independent laboratory — not a generic marketing PDF.
- HPLC purity ≥99% by peak area, with the chromatogram shown.
- US synthesis and finishing, so the chain of custody is documented end to end.
- Cold-chain shipping for lyophilized material, so the product arrives stable.
Peptide Technologies meets each of these and publishes a third-party COA for every lot. Browse the public COA library →
FAQ
What is CJC-1295?
CJC-1295 is a synthetic GHRH analog studied in laboratory endocrine research. It exists in a DAC (long-acting) form and a no-DAC (short-acting) form.
What is the difference between CJC-1295 DAC and no-DAC?
The DAC (drug-affinity complex) form binds albumin for an extended half-life measured in days in laboratory systems. The no-DAC form (mod-GRF 1-29) is short-acting, measured in minutes.
Why is CJC-1295 studied with ipamorelin?
CJC-1295 acts on the GHRH receptor while ipamorelin acts on the GHS (ghrelin) receptor. The two complementary pathways make them a common research pairing.
How is CJC-1295 verified?
Research-grade CJC-1295 is verified by HPLC for purity, mass spectrometry for identity, and an LAL endotoxin assay, reported on a lot-specific third-party COA.
Is CJC-1295 a research chemical?
Yes. CJC-1295 supplied by Peptide Technologies is a research chemical for laboratory use only. Not for use in humans or animals.